Differential Expression of SOX2 and SOX17 in Testicular Germ Cell Tumors
نویسندگان
چکیده
منابع مشابه
genetics of testicular germ cell tumors
testicular germ cell tumor (tgct) is the most solid tumor in 20-40 years old man. tgct account for 95% of testicular tumors and represent a unique type of human cancer from several different perspectives. tgct arise by transformation of germ cells. the transformed germ cells exhibit ploripotentially to differentiate into embryonic. extra-embryonic, and somatic tissue types, and are highly sensi...
متن کاملDifferential Akt signalling in non-seminomatous testicular germ cell tumors.
AIM To investigate the protein kinase B (Akt) signalling proteins phosphatase and tensin homolog (PTEN), phosphorylated-Akt (p-Akt) and cyclin-dependent kinase inhibitor 1B (p27(Kip1)) in non-seminomatous germ cell tumors (NST) with a view to future investigative approaches. MATERIALS AND METHODS The expressions of PTEN, p-Akt and p27(Kip1) were immunohistochemically assessed in 17 teratomas,...
متن کاملBilateral testicular germ cell tumors.
Testicular cancer represents 1% to 1.5% of neoplasias in males and 5% of urologic tumors in general. The incidence of bilateral testicular tumors is 1-5%. Approximately one third of the cases are diagnosed as synchronous, while the other two thirds are diagnosed as metachronous tumors. Additionally, 5% of all patients diagnosed with testicular cancer may have contralateral intratubular germ cel...
متن کاملEstrogen Receptor- Expression in Human Testicular Germ Cell Tumors
Purpose: Estrogen exposure has been linked to a risk for the development of testicular germ cell cancers. The effects of estrogen are now known to be mediated by estrogen receptor (ER)and receptor subtypes, but only ERhas been found in human normal testis. The goal of the present study was to compare the localization and expression levels of these ER subtypes in testicular germ cell cancers (se...
متن کاملDifferential expression of Mediator complex subunit MED15 in testicular germ cell tumors
BACKGROUND Testicular germ cell tumors (TGCT) are the most common cancer entities in young men with increasing incidence observed in the last decades. For therapeutic management it is important, that TGCT are divided into several histological subtypes. MED15 is part of the multiprotein Mediator complex which presents an integrative hub for transcriptional regulation and is known to be deregulat...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2009
ISSN: 0002-9173,1943-7722
DOI: 10.1309/ajcp7mncnbcrn8no